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Documentos Principais

AB2255

Sigma-Aldrich

Anti-GABA B Receptor R2 Antibody

serum, from guinea pig

Sinônimo(s):

G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

guinea pig

Nível de qualidade

100

forma do anticorpo

serum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

rhesus macaque, rat

reatividade da espécie (prevista por homologia)

canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology)

técnica(s)

immunohistochemistry: suitable
western blot: suitable

nº de adesão NCBI

NP_113990

nº de adesão UniProt

O88871

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... GABBR2(9568)

Descrição geral

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Especificidade

This antibody recognizes the C-terminus of rat GABA-B-R2.

Imunogênio

Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2.

Aplicação

Anti-GABA B Receptor R2 Antibody is an antibody against GABA B Receptor R2 for use in IH & WB.

Qualidade

Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region.

Descrição-alvo

Although a band is observed around the calculated molecular weight of 105 kDa, Western Blotting is not a recommened application for this antibody because the band is weak in comparison to other non-specific bands present.

Ligação

Replaces: AB5394

Nota de análise

Control
Purkinje cells in rat mid-brain region

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Francisco Ciruela et al.
The European journal of neuroscience, 32(8), 1265-1277 (2010-09-18)
The stimulation of inhibitory neurotransmitter receptors, such as γ-aminobutyric acid type B (GABA(B) ) receptors, activates G protein-gated inwardly-rectifying K(+) (GIRK) channels, which influence membrane excitability. There is now evidence suggesting that G protein-coupled receptors and G protein-gated inwardly-rectifying K(+)
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Molecular medicine reports, 15(2), 975-980 (2016-12-31)
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