MABN53
Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9
clone 3D9, from mouse
Sinônimo(s):
Dopamine D2 receptor
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
3D9, monoclonal
reatividade de espécies
rat
reatividade da espécie (prevista por homologia)
human (immunogen homology)
técnica(s)
immunocytochemistry: suitable
western blot: suitable
Isotipo
IgMκ
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... DRD2(1813)
rat ... Drd2(24318)
Descrição geral
Problems in the CNS dopaminergic system are thought to be the root cause of some neuropsychiatric disorders. Dopamine D2 receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Dopamine D2 receptor signaling using Nurr1 and ERK may play an important role in mesencephalic dopaminergic neuronal development. Faulty D2 receptors have been common in cases of ROS-dependent hypertension. In addition, defects in DRD2 are associted with alcohol-responsive dystonia, varying susceptability to familial alcoholism as well as a contributing factor to the suicide risk in alcoholics.
Imunogênio
Linear peptide corresponding to human Dopamine D2 receptor.
Aplicação
Immunocytochemistry Analysis: A previous lot was used by an independent laboratory to detect Dopamine D2 receptor in Ntera-2 cells and in rat brain neurons. Courtesy of Glenn Morris, Wolfson Centre for Inherited Neuromuscular Disease.
This Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9 is validated for use in WB, IC for the detection of Dopamine D2 receptor (DRD2).
Qualidade
Evaluated by Western Blot in rat spinal cord tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.
Descrição-alvo
~50 kDa observed
forma física
Format: Purified
Nota de análise
Control
Rat spinal cord tissue lysate
Rat spinal cord tissue lysate
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Endosomal location of dopamine receptors in neuronal cell cytoplasm.
Wolstencroft, EC; Simic, G; thi Man, N; Holt, I; Lam, le T; Buckland, PR; Morris, GE
Journal of Molecular Histology null
Wilber Romero-Fernandez et al.
Molecular neurobiology, 59(10), 5955-5969 (2022-07-14)
The adenosine A2A receptor (A2AR), dopamine D2 receptor (D2R) and metabotropic glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in living cells and in rat striatal neurons. In the current study, we present experimental data supporting the view that
Sanhita Sinharay et al.
Nuclear medicine and biology, 55, 27-33 (2017-10-17)
In vivo imaging biomarkers of various HIV neuropathologies, including dopaminergic dysfunction, are still lacking. Towards developing dopaminergic biomarkers of brain involvement in HIV, we assessed the pre and postsynaptic components of the dopaminergic system in the HIV-1 transgenic rat (Tg)
Dasiel O Borroto-Escuela et al.
Neurotoxicity research, 37(2), 433-444 (2019-11-30)
Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely
Dasiel O Borroto-Escuela et al.
Neurochemical research, 45(1), 5-15 (2019-06-07)
G protein-coupled receptors modulate the synaptic glutamate and GABA transmission of the claustrum. The work focused on the transmitter-receptor relationships in the claustral catecholamine system and receptor-receptor interactions between kappa opioid receptors (KOR) and SomatostatinR2 (SSTR2) in claustrum. Methods used
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