869001-M

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

• Sinônimo(s): Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follitropin, hFSH
• Número CAS: 9002-68-0
• Número MDL: MFCD00131099
• Código UNSPSC: 12352202
• NACRES: NA.32
• fonte biológica: human pituitary glands
• Formulário: lyophilized solid
• Ensaio: ≥90%

Propriedades

• fonte biológica: human pituitary glands
• Nível de qualidade: 200
• esterilidade: non-sterile
• linha de produto: Calbiochem^®
• Ensaio: ≥90%
• Formulário: lyophilized solid
• atividade específica: ≥2000 IU/mg
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• Impurezas: ≤0.1% hCG; ≤0.5% hLH, hTSH
• pI: 4.1
• solubilidade: PBS: soluble
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Ações bioquímicas/fisiológicas

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Advertência

Toxicity: Carcinogenic / Teratogenic (D)

Nota de preparo

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Costrici, N., et al. 1995. Endocrinology136, 4705.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable