8.40124

Span^® 85

for synthesis

• Sinônimo(s): Span^® 85, Sorbitan trioleate, (Z,Z,Z)-Sorbitan tri-9-octadecenoate
• Fórmula empírica (Notação de Hill): C₆₀H₁₀₈O₈
• Número CAS: 26266-58-0
• Peso molecular: 957.49
• Número MDL: MFCD00133820
• Código UNSPSC: 12352108
• Número do índice EC: 247-569-3
• NACRES: NA.22

Propriedades

• pressão de vapor: <1.4 hPa ( 20 °C)
• Nível de qualidade: 200
• forma: liquid
• potência: 39800 mg/kg LD₅₀, oral (Rat)
• kinematic viscosity: 120 cSt(40 °C)
• temperatura de transição: flash point 225 °C
• solubilidade: insoluble <0.001 g/L
• densidade: 0.95 g/cm³ at 20 °C
• temperatura de armazenamento: 2-30°C
• InChI: 1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-53-55(67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2)60-59(54(61)52-66-60)68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27-/t54-,55?,59+,60-/m1/s1
• chave InChI: PRXRUNOAOLTIEF-XDTJCZEISA-N

Descrição

Aplicação

• Macromolecular Stabilization: Span^® 85 is used as a stabilizer for the preparation of PMMA colloidal particles in nonpolar media, proving effective in maintaining stability under various conditions, crucial for industrial applications in coatings and advanced materials manufacturing (Liu et al., 2022).


• Enhanced Nanoemulsion Systems: It plays a critical role in the formation of aerosolized nanoemulsion systems encapsulating docetaxel and curcumin, utilized in cancer therapy to improve therapeutic outcomes through enhanced drug delivery mechanisms (Abdul Rahman et al., 2020).


• Skin Protection Formulations: Span^® 85 is integral in the formulation and clinical assessment of microemulsion-based hydrogels for UV protection, demonstrating its utility in skincare products by enhancing sun protection factor and skin compatibility (Ebrahimi et al., 2019).


• Transdermal Drug Delivery: This surfactant is utilized in tailoring novel soft nano-vesicles, known as ′Flexosomes′, to enhance transdermal drug delivery, which is pivotal for non-invasive therapeutic applications and improving patient compliance (Mansour et al., 2019).

Nota de análise

Hydroxyl value: 55 - 75
Saponification value: 170 - 190
Identity (IR): passes test
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Informações legais

Span is a registered trademark of Croda International PLC

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 437.0 °F
• Ponto de fulgor (°C): 225 °C