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Merck
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Key Documents

09569

Supelco

Span® 80

greener alternative

suitable for GC

Sinônimo(s):

Sorbitan monooleate, Span® 80

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About This Item

Fórmula empírica (Notação de Hill):
C24H44O6
Número CAS:
Peso molecular:
428.60
Beilstein:
8172514
Número CE:
Número MDL:
Código UNSPSC:
12000000
ID de substância PubChem:
NACRES:
NA.21

descrição

non-ionic

Nível de qualidade

peso molecular

428.60 g/mol

características do produto alternativo mais ecológico

Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

técnica(s)

LPLC: suitable
gas chromatography (GC): suitable
protein quantification: suitable

índice de refração

n20/D 1.48 (lit.)

Valor HLB

4.6±0.1

densidade

0.99 g/mL at 20 °C
0.986 g/mL at 25 °C (lit.)

categoria alternativa mais ecológica

cadeia de caracteres SMILES

[H][C@@](O)(COC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

chave InChI

NWGKJDSIEKMTRX-AAZCQSIUSA-N

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Descrição geral

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is biodegradable surfactant, thus aligns with "Use of Renewable Feedstocks" and "Design for Degradation" principles of Green Chemistry, and belongs to "12 principles aligned" category of our greener alternatives.

Aplicação

A non-ionic surfactant that can be used to form oil-in-water emulsions and in combination with low HLB surfactants can form water-in-oil emulsions. EPA approved oil spill dispersant.

Informações legais

Span is a registered trademark of Croda International PLC

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves


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Abstract For the development of an effective self-nanoemulsifying drug delivery system (SNEDDS) of poorly soluble drugs, the knowledge of the solubility in its oil phase and SNEDDS are one of the most important factors to avoid possibility of drug to
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(1-2), 1-7 (2012-02-15)
In the search for an optimal approach for the transcutaneous immunization (TCI) of hepatitis B surface antigen (HBsAg), two vesicle formulations, L595 vesicles (composed of sucrose-laurate ester and octaoxyethylene-laurate ester) and sPC vesicles (composed of soybean-phosphatidylcholine and Span-80) were prepared
Chenguang Zhou et al.
Molecular pharmaceutics, 9(2), 201-210 (2011-12-14)
Nonionic surfactant vesicles, or SPANosomes (SPs), comprised of cationic lipid and sorbitan monooleate (Span 80) were synthesized and evaluated as small interfering RNA (siRNA) vectors. The SPs had a mean diameter of less than 100 nm and exhibited excellent colloidal
Xiazhong Ren et al.
International journal of pharmaceutics, 431(1-2), 130-137 (2012-05-03)
This study is the first to investigate and demonstrate the potential of microemulsions (MEs) for sustained release parenteral drug delivery, due to phase transition behavior in aqueous environments. Phase diagrams were constructed with Miglyol 812N oil and a blend of

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