662015

U 18666A

≥95% (HPLC), lyophilized solid, δ8-sterol isomerase inhibitor, Calbiochem^®

• Sinônimo(s): U18666A, 3β-(2-Diethylaminoethoxy)androst-5-en-17-one, HCl
• Fórmula empírica (Notação de Hill): C₂₅H₄₁NO₂ · xHCl
• Número CAS: 3039-71-2
• Peso molecular: 387.60 (free base basis)
• Número MDL: MFCD00210908
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nome do produto: U18666A, A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.
• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: lyophilized solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: water: 10 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]
• InChI: 1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H
• chave InChI: ICPRVJHNLABCSA-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable, amphiphilic amino-steroid that alters intracelluar membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol. Reported to exert its effects via the inhibition of 2,3-oxidosqualene-lanosterol cyclase activity. Also reported to inhibit the activity of Δ⁸-sterol isomerase.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Activity of δ8-sterol isomerase

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Hall, A.M., et al. 2003. Pigment Cell Res.16, 149.
Kobayashi, T., et al. 1998. Nature392, 193.
Liscum, L. and Faust, J.R., 1989. J. Biol. Chem.264, 11796.
Sexton, R.C., et al. 1983. Biochemistry22, 5687.
Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res.150, 343.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable