U3633

U 18666A

powder

• Sinônimo(s): (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
• Fórmula empírica (Notação de Hill): C₂₅H₄₁NO₂·HCl
• Número CAS: 3039-71-2
• Peso molecular: 424.06
• Número MDL: MFCD00210908
• Código UNSPSC: 12352200
• ID de substância PubChem: 24724638
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to off-white
• pf: 195-196.5 °C (lit.)
• solubilidade: H₂O: 10 mg/mL≥
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl[H].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H])OCCN(CC)CC
• InChI: 1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1
• chave InChI: GZFYZYBWLCYBMI-MYZJJQSMSA-N

Descrição

Descrição geral

U18666A, a cationic amphiphile/sterol, has a diethylaminoethyl chain linked to the 3-hydroxyl. It is an androstenolone derivative.

Aplicação

U 18666A has been used in fibroblast controls to study the mechanism of increase in autophagy in Niemann-Pick Disease Type C (NPC) cells.

U 18666A has been used:

• as a competitive inhibitor of the Niemann-Pick disease, type C (NPC2) binding partner Niemann-Pick C1 (NPC1) to treat symbiotic and aposymbiotic adult Aiptasia to study the effect of global sterol transport inhibition
• in treating seminiferous tubules to study its effects on the localization pattern of VPS35-positive vesicles
• to study the U18666A treatment effects on early endosomes and late endosomes/multivesicular bodies (MVBs)
• as an NPC1 inhibitor to test its in vivo efficacy and study its effects on filovirus entry and infection

Ações bioquímicas/fisiológicas

Inhibitor of cholesterol synthesis (inhibits desmosterol Δ24-reductase). Weak inhibitor of hedgehog (hh) signaling.

U18666A, a Niemann-Pick phenotype inducer, can inhibit the lysosomal cholesterol export and Ebola infection.

Nota de preparo

U 18666A is soluble in water at 10 mg/ml.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)