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Sigma-Aldrich

SKF-525A, Hydrochloride

Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

Sinônimo(s):

SKF-525A, Hydrochloride, Proadifen

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About This Item

Fórmula empírica (Notação de Hill):
C23H31NO2 · xHCl
Número CAS:
62-68-0
Peso molecular:
353.50 (free base basis)
Número MDL:
MFCD00055151
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (TLC)

forma

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
desiccated (hygroscopic)

cor

white

solubilidade

water: 20 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

−20°C

InChI

1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H

chave InChI

FHIKZROVIDCMJA-UHFFFAOYSA-N

Descrição geral

Cell permeable. Blocks glibenclamide-sensitive K+ channels (IC50 = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.
Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.

Ações bioquímicas/fisiológicas

Cell permeable: yes
Primary Target
nNOS
Product does not compete with ATP.
Reversible: no
Target IC50: 90 µM against neuronal nitric oxide synthase

Advertência

Toxicity: Harmful (C)

Reconstituição

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Outras notas

Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol.252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol.45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther.198, 347.
Grasdalen, J., et al. 1975. FEBS Lett.60, 240.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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