565851

SHP1/2 PTPase Inhibitor, NSC-87877

The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): SHP1/2 PTPase Inhibitor, NSC-87877, 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
• Fórmula empírica (Notação de Hill): C₁₉H₁₁N₃Na₂O₇S₂
• Número CAS: 56932-43-5
• Peso molecular: 503.42
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: red-brown
• solubilidade: water: 10 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;
• chave InChI: YOGRUDWAJPVHEL-LLDDCTHSSA-L

Descrição

Descrição geral

A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC₅₀ = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
SHP1/2 PTPase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Chen, L., et al. 2006. Mol. Pharmacol.70, 562.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable