5.34337

CADA

≥98% (HPLC), solid, HIV inhibitor, Calbiochem^®

• Sinônimo(s): HIV Inhibitor, CADA, 1-Benzyl-7-methylene-5,9-ditosyl-5,9-diaza-azoniacyclododecan-1-ium chloride, CD4 Inhibitor, CADA
• Fórmula empírica (Notação de Hill): C₃₁H₃₉N₃O₄S₂ · xHCl
• Peso molecular: 581.79 (free base basis)
• Código UNSPSC: 51111800
• NACRES: NA.77

Propriedades

• Nome do produto: HIV Inhibitor, CADA,
• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 10 mg/mL; water: insoluble
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC₅₀ = 300 nM to 3.3 µM) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H, AE, and O and human herpesvirus 7 (HHV-7; IC₅₀, 300 nM to 1.5 µM) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.

Ações bioquímicas/fisiológicas

Reversible: yes

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Outras notas

Vermeire, K., et al. 2008. Curr. HIV Res.6, 246.
Bell, T. W., et al. 2006. J. Med. Chem.49, 1291.
Vermeire, K., et al. 2004. AIDS.18, 2115.
Vermeire, K., et al. 2002. Virology.302, 342.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable