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Documentos Principais

52332

Sigma-Aldrich

Phenylmethylsulfonyl Fluoride

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

Sinônimo(s):

Phenylmethylsulfonyl Fluoride, Benzylsulfonyl Fluoride, PMSF

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About This Item

Fórmula empírica (Notação de Hill):
C7H7FO2S
Número CAS:
Peso molecular:
174.19
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

Nível de qualidade

Ensaio

≥99% (GC)

forma

crystalline solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
desiccated

cor

white to off-white

solubilidade

ethanol: soluble
isopropanol: soluble
methanol: soluble

Condições de expedição

ambient

temperatura de armazenamento

10-30°C

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

chave InChI

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Descrição geral

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).

Ações bioquímicas/fisiológicas

Cell permeable: no
Primary Target
serine proteases
Product does not compete with ATP.
Reversible: no

Advertência

Toxicity: Corrosive (L)

Reconstituição

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
t½ = 1 hour at pH 7.5. Effective concentration: 50 μM.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Seitz, R., et al. 1993. Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.
Chang, C.T., et al. 1992. Biochem. Int.28, 707.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Skull and crossbonesCorrosion

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Acute Tox. 3 Oral - Skin Corr. 1B

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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