93482
Phenylmethanesulfonyl fluoride solution
~0.1 M in ethanol (T)
Sinônimo(s):
Benzylsulfonyl fluoride, PMSF
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About This Item
Número CAS:
Beilstein:
2088311
Número MDL:
Código UNSPSC:
12352202
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
fonte biológica
microbial
synthetic
Nível de qualidade
Formulário
liquid
concentração
~0.1 M in ethanol (T)
densidade
0.797 g/mL at 20 °C
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
FS(=O)(=O)Cc1ccccc1
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
chave InChI
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Aplicação
Phenylmethanesulfonyl fluoride solution has been used as a component in the cell lysate buffer in breast adenocarcinoma cell line, fibrosarcoma cell line and D5 hindbrain and spinal cord neural progenitors.
Ações bioquímicas/fisiológicas
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.
Phenylmethanesulfonyl fluoride (PMSF) is a serine protease inhibitor. It binds covalently to active site residue of proteases and prevents proteolytic activity. PMSF is used in cell lysate buffers during protein purification to prevent target protein degradation. PMSF effectively inhibits the naloxone-precipitated withdrawal jumping.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
Código de classe de armazenamento
3 - Flammable liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
53.6 °F - closed cup
Ponto de fulgor (°C)
12 °C - closed cup
Equipamento de proteção individual
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Intraperitoneal (IP) injection of the serine proteinase inhibitor phenylmethylsulfonyl fluoride (PMSF) produced dose-dependent analgesia in Sprague-Dawley rats. AD50 was 2.9 +/- 1.4 (S.E.) mg kg-1, the analgesia was antagonized by naloxone but unaffected by atropine. PMSF significantly enhanced the analgesic
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