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93482

Sigma-Aldrich

Phenylmethanesulfonyl fluoride solution

~0.1 M in ethanol (T)

Sinônimo(s):

Benzylsulfonyl fluoride, PMSF

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About This Item

Número CAS:
329-98-6
Beilstein:
2088311
Número MDL:
MFCD00007424
Código UNSPSC:
12352202
ID de substância PubChem:
57653563
NACRES:
NA.77

fonte biológica

microbial
synthetic

Nível de qualidade

200

forma

liquid

concentração

~0.1 M in ethanol (T)

densidade

0.797 g/mL at 20 °C

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

FS(=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

chave InChI

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Aplicação

Phenylmethanesulfonyl fluoride solution has been used as a component in the cell lysate buffer in breast adenocarcinoma cell line, fibrosarcoma cell line and D5 hindbrain and spinal cord neural progenitors.

Ações bioquímicas/fisiológicas

Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.
Phenylmethanesulfonyl fluoride (PMSF) is a serine protease inhibitor. It binds covalently to active site residue of proteases and prevents proteolytic activity. PMSF is used in cell lysate buffers during protein purification to prevent target protein degradation. PMSF effectively inhibits the naloxone-precipitated withdrawal jumping.

Pictogramas

FlameExclamation mark
GHS02,GHS07

Palavra indicadora

Danger

Frases de perigo

H225 - H315 - H319

Classificações de perigo

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

53.6 °F - closed cup

Ponto de fulgor (°C)

12 °C - closed cup

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificados de análise (COA)

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Intraperitoneal (IP) injection of the serine proteinase inhibitor phenylmethylsulfonyl fluoride (PMSF) produced dose-dependent analgesia in Sprague-Dawley rats. AD50 was 2.9 +/- 1.4 (S.E.) mg kg-1, the analgesia was antagonized by naloxone but unaffected by atropine. PMSF significantly enhanced the analgesic
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