5.09708

SKF-97541

• Sinônimo(s): SKF-97541, GABA _B Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA
• Fórmula empírica (Notação de Hill): C₄H₁₂NO₂P
• Número CAS: 127729-35-5
• Peso molecular: 137.12
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (TLC)
• Nível de qualidade: 100
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: water: 100 mM
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)/p+1
• chave InChI: NHVRIDDXGZPJTJ-UHFFFAOYSA-O

Descrição

Descrição geral

A highly potent agonist of GABA_B receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC₅₀ = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.

A highly potent agonist of GABA_B receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC₅₀ = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Ações bioquímicas/fisiológicas

Primary Target
GABA_B

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Kaye, A.D., et al. 2004. Anesth. Analg.99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol.142, 1038.

Seabrook, G.R., et al. 1990. Br. J. Pharmacol.101, 949.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable