5.05881

(R)-(+)-SKF38393 Hydrochloride

• Sinônimo(s): (R)-(+)-SKF38393 Hydrochloride, Dopamine D₁/D₅ Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393
• Fórmula empírica (Notação de Hill): C₁₆H₁₇NO₂ · xHCl
• Número CAS: 81702-42-3
• Peso molecular: 255.31 (free base basis)
• Número MDL: MFCD00055189
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: water: 100 mM
• temperatura de armazenamento: −20°C
• InChI: 1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
• chave InChI: YEWHJCLOUYPAOH-PFEQFJNWSA-N

Descrição

Descrição geral

A benzazepine derivative that acts as a selective Dopamine D₁/D₅ receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.

A benzazepine derivative that acts as a selective Dopamine D₁/D₅ receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.

Ações bioquímicas/fisiológicas

Primary Target
D₁

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Trampus, M. et al. 1993. J. Pharmacol.235, 83.
Cooper, S. J. et al. 1990. Psychopharmacol.100, 182.
Dubois, A. et al. 1986. Neurosci.19, 125.
Kaiser, C. C. et al. 1982. J. Med. Chem.25, 697.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable