365251

Gö 6983

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.

• Sinônimo(s): Gö 6983, 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
• Fórmula empírica (Notação de Hill): C₂₆H₂₆N₄O₃
• Número CAS: 133053-19-7
• Peso molecular: 442.51
• Número MDL: MFCD04040031
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: orange-red
• solubilidade: DMSO: 100 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)ccc(c3)OC
• InChI: 1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
• chave InChI: LLJJDLHGZUOMQP-UHFFFAOYSA-N

Descrição

Descrição geral

A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC₅₀ = 7 nM for PKC_α and PKC_β; 6 nM for PKC_γ; 10 nM for PKC_δ; 60 nM for PKC_ζ). Gö 6983 does not effectively inhibit PKC_µ (IC₅₀ = 20 µM) and can thus be used to differentiate PKC_µ from other PKC isozymes.

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC₅₀ = 7 nM for PKC_α and PKC_β; 6 nM for PKC_γ; 10 nM for PKC_δ; and 60 nM for PKC_ζ). Gö 6983 does not effectively inhibit PKC_µ (IC₅₀ = 20 µM) and can thus be used to differentiate PKC_µ from other PKC isozymes.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
PKCα and PKCβ

Product competes with ATP.

Reversible: yes

Target IC₅₀: 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ

Advertência

Toxicity: Standard Handling (A)

Outras notas

Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3