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Key Documents

324410

Sigma-Aldrich

Dynasore

≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®

Sinônimo(s):

Dynamin Inhibitor I, Dynasore, 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin

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About This Item

Fórmula empírica (Notação de Hill):
C18H14N2O4
Número CAS:
304448-55-3
Peso molecular:
322.31
Código UNSPSC:
12352200
NACRES:
NA.77

product name

Dynamin Inhibitor I, Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
protect from light

cor

pale yellow

solubilidade

DMSO: 16 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

2-8°C

InChI

1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

chave InChI

SYNDQCRDGGCQRZ-VXLYETTFSA-N

Descrição geral

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Environmental Hazard (N)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Young, A., et al. 2009. Biochem. J., In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.
Macia. E., et al. 2006. Dev. Cell10, 839.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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