203996

N-Butyldeoxynojirimycin, Hydrochloride

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II.

• Sinônimo(s): N-Butyldeoxynojirimycin, Hydrochloride, NB-DNJ, HCl, N-Butyl-DNJ, HCl
• Fórmula empírica (Notação de Hill): C₁₀H₂₁NO₄ · xHCl
• Número CAS: 72599-27-0
• Peso molecular: 219.28 (free base basis)
• Número MDL: MFCD00272581
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: white
• solubilidade: water: 1 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
• chave InChI: UQRORFVVSGFNRO-UTINFBMNSA-N

Descrição

Descrição geral

A non-hormonal, alkylated imino sugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays broad-spectrum anti-viral effects by inhibiting the processing of viral surface glycoproteins. Shown to reversibly induce infertility in male mammals.

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays a broad-spectrum anti-viral activity by aiding the misfolding of glycoproteins. Shown to reversibly induce infertility in male mammals. Does not inhibit cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Ceramide-specific glycosyltransferases

Product does not compete with ATP.

Reversible: yes

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Outras notas

Dwek, R.A., et al. 2002. Nat. Rev. Drug Discovery1, 65.
van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA99, 17173.
Platt, F.M., et al. 1997. Science276, 428.
Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA91, 2235.
Platt, F.M., et al. 1994. J. Biol. Chem.269, 8362.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable