191500

1-Azakenpaullone

A Kenpaullone analog that acts as a potent and ATP-competitive inhibitor of GSK-3β.

• Sinônimo(s): 1-Azakenpaullone, 1-AKP
• Fórmula empírica (Notação de Hill): C₁₅H₁₀BrN₃O
• Número CAS: 676596-65-9
• Peso molecular: 328.16
• Número MDL: MFCD09037522
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥94% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: tan
• solubilidade: DMSO: 100 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• chave InChI: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Descrição

Descrição geral

A Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM), and displays ~100-200 fold greater selectivity over Cdk1/B and Cdk5/p25 (IC₅₀ = 2 µM and 4.2 µM, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 191501).

A Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC₅₀ = 2.0 µM and 4.2 µM, respectively).

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
GSK-3β

Product competes with ATP.

Reversible: no

Target IC₅₀: 18 nM against GSK-3β

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable