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178273

Sigma-Aldrich

Aphidicolin

≥98% (HPLC), solid, DNA polymerase α and δ inhibitor, Calbiochem

Sinônimo(s):

Aphidicolin

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About This Item

Fórmula empírica (Notação de Hill):
C20H34O4
Número CAS:
38966-21-1
Peso molecular:
338.48
Número MDL:
MFCD00083214
Código UNSPSC:
12352200
NACRES:
NA.77

Nome do produto

Aphidicolin, Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.

Nível de qualidade

100

descrição

Merck USA index - 14, 727

Ensaio

≥98% (HPLC)

Formulário

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze

cor

white

solubilidade

DMSO: 50 mg/mL
ethanol: soluble
methanol: soluble

Condições de expedição

ambient

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

chave InChI

NOFOAYPPHIUXJR-APNQCZIXSA-N

Descrição geral

A cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744).

Ações bioquímicas/fisiológicas

Cell permeable: yes
Primary Target
DNA polymerase α, DNA polymerase δ
Product does not compete with ATP.
Reversible: no

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Outras notas

Borner, M.M., et al. 1995. Cancer Res.55, 2122.
Poluha, W., et al. 1995. Oncogene 10, 185.
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
Hubermann, J.A. 1981. Cell23, 647.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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