1.08307

Tris(hidroximetil)-aminometano

(Trometamol) high purity, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JPC, USP

• Sinônimo(s): 2-amino-2-(hidroximetil)-1,3-propanodiol, THAM, Tris base, Trometamol
• Fórmula linear: NH₂C(CH₂OH)₃
• Número CAS: 77-86-1
• Peso molecular: 121.14
• Beilstein: 741883
• Número MDL: MFCD00004679
• Código UNSPSC: 12352209
• Número do índice EC: 201-064-4

Propriedades

• Agency: BP; ChP; JPC; Ph. Eur.; USP
• Nível de qualidade: 500
• pressão de vapor: 0.0267 hPa ( 20 °C)
• descrição: EMPROVE^® EXPERT Ph Eur,BP,JPC,USP,ACS
• linha de produto: EMPROVE^® EXPERT
• Formulário: solid
• Características: RNase and DNase free
• pH: 10.2-10.6 (20 °C, 6 g/L in H₂O)
• faixa de pH útil: 7-9
• pKa (25 °C): 8.1
• p.e.: 219-220 °C/10 mmHg (lit.); 219-220 °C/13.3 hPa
• pf: 167-172 °C (lit.)
• densidade: 1.35 g/cm³ at 23 °C
• aplicação(ões): liquid formulation; pharmaceutical; semi-solid formulation
• temperatura de armazenamento: no temp limit
• cadeia de caracteres SMILES: NC(CO)(CO)CO
• InChI: 1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
• chave InChI: LENZDBCJOHFCAS-UHFFFAOYSA-N

Descrição

Descrição geral

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.
Due to its low polyoxymethylene limits, Tris(hydroxymethyl)aminomethane (Trometamol) Emprove^® Expert is suitable for use at elevated concentrations without risking precipitation. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.

Informações legais

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable