09-241

Anti-phospho JAK-2 (Tyr570) Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), tyrosine-protein kinase JAK2
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: rat, human, pig, horse
• reatividade da espécie (prevista por homologia): primate (based on 100% sequence homology), equine (based on 100% sequence homology), porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• técnica(s): western blot: suitable
• nº de adesão NCBI: NP_004963
• nº de adesão UniProt: O60674
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: phosphorylation (pTyr570)
• Informações sobre genes: human ... JAK2(3717)

Descrição

Descrição geral

JAK-2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK-2. JAK-2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. Within the JAK-2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor.

Especificidade

This antibody recognizes JAK-2 when phosphorylated on Tyr570.

Imunogênio

Epitope: Phosphorylated Tyr570

KLH-conjugated linear peptide corresponding to human JAK-2 phosphorylated at Tyr570.

Aplicação

Research Category
Signaling

Research Sub Category
Cytokines & Cytokine Receptors

This Anti-phospho JAK-2 (Tyr570) Antibody is validated for use in WB, WB, WB for the detection of phospho JAK-2 (Tyr570).

Qualidade

Evaluated by Western Blot in transfected HEK293T cell lysates.

Western Blot Analysis: 0.05 ug/mL of this antibody detected JAK-2 on 10 µg of transfected HEK293T cell lysates.

Descrição-alvo

~ 125 kDa

forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Transfected HEK293T cell lysates

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable