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Documentos Principais

06-1425

Sigma-Aldrich

Anti-phospho-TAK1 (Ser412) Antibody

from rabbit, purified by affinity chromatography

Sinônimo(s):

Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

human, mouse

técnica(s)

western blot: suitable

nº de adesão NCBI

NP_663306

nº de adesão UniProt

O43318

Condições de expedição

wet ice

modificação pós-traducional do alvo

phosphorylation (pSer412)

Informações sobre genes

human ... MAP3K7(6885)

Descrição geral

TAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.

Especificidade

This antibody recognizes TAK1 phosphorylated at Ser412.

Imunogênio

Epitope: Phosphorylated Ser412
KLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412.

Aplicação

Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.

Qualidade

Evaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates.

Descrição-alvo

~70 kDa observed

Nota de análise

Control
Lambda phosphatase treated and untreated Murine RAW cell lysates

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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