E-006
EDDP perchlorate
ampule of 10 mg, certified reference material, Cerilliant®
Sinônimo(s):
EDDP perchlorate, 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate
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About This Item
Fórmula empírica (Notação de Hill):
C20H23N · HClO4
Número CAS:
Peso molecular:
377.86
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24
Produtos recomendados
grau
certified reference material
Nível de qualidade
Formulário
solid
Características
Snap-N-Spike®/Snap-N-Shoot®
embalagem
ampule of 10 mg
fabricante/nome comercial
Cerilliant®
controle de medicamentos
regulated under CDSA - not available from Sigma-Aldrich Canada
técnica(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
aplicação(ões)
forensics and toxicology
Formato
neat
temperatura de armazenamento
−20°C
Descrição geral
A Certified Reference Material of the major urinary metabolite of methadone. Methadone, sold under various trade names such as Symoron, Amidone or Methadose®, is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. Suitable uses for this reference standard include as starting material in preparation of calibrators and controls for LC/MS or GC/MS methods in methadone testing for applications in clinical toxicology or forensic analysis.
Aplicação
- DNA precipitation: This compound is vital for DNA precipitation protocols where it facilitates the aggregation of DNA fragments by reducing their solubility in water. This application is essential for genetic engineering and molecular biology experiments (Park et al., 2023).
- Cell culture: In cell culture, ammonium sulfate is used to control the osmotic pressure of culture media, which is crucial for maintaining the health and viability of cultured cells, thus supporting tissue engineering and cellular research (Qin et al., 2024).
Informações legais
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Descrição
Preços
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 3 Oral - STOT SE 3
Órgãos-alvo
Central nervous system
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Mathew George et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(4), 432-435 (2012-08-18)
Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate
Mei-Han Huang et al.
Toxicology, 280(1-2), 1-9 (2010-11-26)
Methadone (Mtd) is a widely used opioid drug associated with the side effect of hyperprolactinemia. The mechanism of how Mtd induces prolactin secretion remains unclear. The effects of Mtd and its two main metabolites (EDDP: (±)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium percholarate and EMDP: 2-ethyl-5-methyl-3,3-dipnehyl-1-pyrroline)
Ricarda Jantos et al.
Forensic science international, 226(1-3), 254-260 (2013-02-21)
Body fluids and tissues in 16 methadone (MTD)-associated fatalities were investigated to find out whether analysis of MTD and its metabolite 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) following enantioselective separation of both compounds may assist in the interpretation of MTD findings. Individual case histories
Cristiana Gambelunghe et al.
Annals of clinical and laboratory science, 43(1), 22-30 (2013-03-07)
It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment
Maksymilian Kulza et al.
Przeglad lekarski, 67(10), 925-928 (2010-01-01)
Methadone maintenance therapy is one of the most popular treatments for opiate addiction. The easiest and the most reliable way to monitor the accuracy of the therapy is determination of methadone and its metabolites in biological material. The aim of
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