D-065

Dehydroepiandrosterone 3-sulfate (DHEAS) sodium salt solution

1.0 mg/mL in methanol (as free sulfate), ampule of 1 mL, certified reference material, Cerilliant^®

• Sinônimo(s): Dehydroepiandrosterone 3-sulfate sodium salt
• Fórmula empírica (Notação de Hill): C₁₉H₂₈NaO₅S
• Número CAS: 1099-87-2
• Peso molecular: 391.48
• Número CE: 200-659-6
• Número MDL: MFCD00010470
• Código UNSPSC: 41116107
• ID de substância PubChem: 329798626
• NACRES: NA.24

Propriedades

• grau: certified reference material
• Nível de qualidade: 300
• forma: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• embalagem: ampule of 1 mL
• fabricante/nome comercial: Cerilliant^®
• concentração: 1.0 mg/mL in methanol (as free sulfate)
• técnica(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicação(ões): clinical testing
• formato: single component solution
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C([C@@]1(C)CC[C@@]23[H])CC[C@]1([C@](CC=C4C[C@H](CC[C@]34C)OS([O-])(=O)=O)2[H])[H].[Na+]
• InChI: 1S/C19H28O5S.Na/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18;/h3,13-16H,4-11H2,1-2H3,(H,21,22,23);/q;+1/p-1/t13-,14-,15-,16-,18-,19-;/m0./s1
• chave InChI: GFJWACFSUSFUOG-ZJTJBYBXSA-M

Descrição

Descrição geral

DHEAS is a metabolite of dehydroepiandrosterone (DHEA), an endogenous steroid that has been implicated in a broad range of biological effects in humans and other mammals. DHEAS levels are measured by LC-MS/MS for determination of excess adrenal activity as observed in adrenal cancer, certain forms of congenital adrenal hyperplasia (CAH), and polycystic ovary syndrome.

Aplicação

• Pharmacokinetic Assessment: Research highlighted the utilization of DHEAS sodium salt in pharmacokinetic studies, exemplified by the development of an LC-MS/MS method to measure Sodium Tanshinone IIA Sulfonate in human plasma. This methodology underscores the role of DHEAS as a critical steroid hormone in biomedicine, enabling precise quantification and study of drug metabolites in clinical settings (Qin et al., 2016).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H225,H301 + H311 + H331,H370
• Declarações de precaução: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órgãos-alvo: Eyes
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 49.5 °F - closed cup
• Ponto de fulgor (°C): 9.7 °C - closed cup