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870608H

Avanti

4-HNE-dimethylacetal

Avanti Research™ - A Croda Brand 870608H, hexane solution

Sinônimo(s):

(E)-4R-hydroxynonenal-dimethylacetal (Each vial contains 6.8mg which yields ~5.2mg 4-HNE after deprotection)

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About This Item

Fórmula empírica (Notação de Hill):
C11H22O3
Número CAS:
119009-01-7
Peso molecular:
202.29
Código UNSPSC:
12352211
NACRES:
NA.25

forma

hexane solution

embalagem

pkg of 1 × 1 mL (870608H-5mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 870608H

concentração

6.8 mg/mL (870608H-5mg)

tipo de lipídio

phosphoglycerides
bioactive lipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CCCCC[C@@H](O)/C=C/C(OC)OC

Descrição geral

4-Hydroxynonenal (4-HNE or HNE) is an α,β-unsaturated hydroxyalkenal which is produced by lipid peroxidation in cells. 4-HNE has been hypothesized by several researchers to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.
The dimethylacetal derivative is a more stable form of 4-HNE which is good for long term storage of the compound during use. It can be easily converted to 4-HNE in the presence of acid.

Embalagem

2 mL Amber Glass Sealed Ampule (870608H-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Palavra indicadora

Danger

Classificações de perigo

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3

Órgãos-alvo

Central nervous system, Nervous system

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

-14.8 °F - closed cup

Ponto de fulgor (°C)

-26.0 °C - closed cup

Certificados de análise (COA)

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Kamelija Zarkovic
Molecular aspects of medicine, 24(4-5), 293-303 (2003-08-02)
The development of oxidative stress, in which production of highly reactive oxygen species (ROS) overwhelms antioxidant defenses, is a feature of many neurological diseases: ischemic, inflammatory, metabolic and degenerative. Oxidative stress is increasingly implicated in a number of neurodegenerative disorders
Rajendra Sharma et al.
European journal of biochemistry, 271(9), 1690-1701 (2004-04-21)
4-Hydroxy-2-trans-nonenal (4-HNE), one of the major end products of lipid peroxidation, has been shown to induce apoptosis in a variety of cell lines. It appears to modulate signaling processes in more than one way because it has been suggested to
Yogesh C Awasthi et al.
Free radical biology & medicine, 37(5), 607-619 (2004-08-04)
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. Glutathione S-transferases (GSTs) can modulate
Neven Zarkovic
Molecular aspects of medicine, 24(4-5), 281-291 (2003-08-02)
The review is focused on the currently major aspect of 4-hydroxynonenal (HNE) research--studies that combine biological activities of the aldehyde together with the methods of its identification in cells and tissues. Because there were some excellent reviews on HNE published
N Zarković et al.
Life sciences, 65(18-19), 1901-1904 (1999-11-27)
Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and
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