700052P
Avanti
22(R)-hydroxycholesterol-d7
Avanti Research™ - A Croda Brand
Sinônimo(s):
25,26,26,26,27,27,27-heptadeuterocholest-5-ene-3β,22R-diol
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About This Item
Fórmula empírica (Notação de Hill):
C27H39O2D7
Número CAS:
Peso molecular:
409.70
Código UNSPSC:
41141804
NACRES:
NA.25
Produtos recomendados
descrição
cholest-5-ene-3β,22(R)-diol-d7
Ensaio
>99% (TLC)
forma
powder
embalagem
pkg of 1 × 1 mg (700052P-1mg)
fabricante/nome comercial
Avanti Research™ - A Croda Brand
aplicação(ões)
lipidomics
metabolomics
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Descrição geral
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in the neonate brain. 22(R)-hydroxycholesterol-d7 is a deuterated form of 22(R)-hydroxycholesterol.
Ações bioquímicas/fisiológicas
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand and is a key for the receptor activation.. 22(R)-HC promotes mesenchymal stem cell osteogenesis along with other oxysterols. It also regulates cholesterol homeostasis and suppresses prostate tumor progression. Low levels of 22(R)-HC is observed in Alzheimer′s disease and may be implicated in neuroinflammation and neurodegenerative diseases.
Embalagem
5 mL Amber Glass Screw Cap Vial (700052P-1mg)
Informações legais
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de classe de armazenamento
11 - Combustible Solids
Certificados de análise (COA)
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Chih-Pin Chuu et al.
Anticancer research, 30(9), 3643-3648 (2010-10-15)
Previously, we and other groups reported that liver X receptor (LXR) agonists T0901317, 22(R)-hydroxycholesterol, and 24(S)-hydroxycholesterol suppressed the proliferation of prostate and breast cancer cells. In this study, we report that T0901317 and 22(R)-hydroxycholesterol treatment inhibited the proliferation of different
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Donglin Ma et al.
Biochimie, 103, 101-108 (2014-05-06)
Abnormal lipid metabolism may contribute to the pathogenesis of non-alcoholic steatohepatitis (NASH). The ATP-binding cassette transporter A1 (ABCA1) protein mediates the transport of cholesterol and phospholipids from cells to apolipoprotein A-I (apoA-I) to generate nascent HDL particles. Previous studies revealed
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