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Key Documents

QBD10773

Sigma-Aldrich

dPEG®24-biotin acid

>95% (HPLC)

Sinônimo(s):

Biotin-PEG-acid, Biotin-PEG24-COOH, PEG1000 biotin acid, PEG24-biotin acid

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About This Item

Fórmula empírica (Notação de Hill):
C61H117N3O28S
Peso molecular:
1372.65
Número MDL:
Código UNSPSC:
12352106
NACRES:
NA.22

Ensaio

>95% (HPLC)

forma

solid or viscous liquid

adequação da reação

reaction type: Biotinylations
reaction type: Pegylations

arquitetura do polímero

shape: linear
functionality: monofunctional

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Características e benefícios

dPEG24 biotin acid consists of a biotin molecule conjugated to a single molecular weight polyethylene glycol chain of discrete length (dPEG). The dPEG chain is 76 atoms (90.1 Å) long. The distal end of the dPEG chain terminates with a propionic acid group. The terminal acid is available for direct conjugation to free amines or functionalization as an active ester. Amphiphilic dPEG24 biotin acid can be dissolved both in water or aqueous buffer and in organic solvent. It does not cause aggregation or precipitation of biomolecules. Using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry, dPEG24 biotin acid can be coupled directly to free primary amines in aqueous media. These free amines can be on a protein, peptide, or the treated surface of a nanoparticle. Moreover, the acid moiety can be functionalized with other reactive groups for coupling directly to surfaces such as glass, gold, or magnetic nanoparticles. The linker length of dPEG24 biotin acid is much longer than the linker lengths of LC-biotin and of LC-LC-biotin and is a monodisperse equivalent of a PEG1000. The performance characteristics of dPEG24-biotin acid are quite superior to both LC-biotin and LC-LC-biotin.

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Informações legais

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Thurid Boetel et al.
Biochemical and biophysical research communications, 349(1), 296-302 (2006-08-29)
The biological function of prion protein (PrP) and the physiological relevance of its truncated subtypes and glycoforms is still enigmatic. In this paper, we adduce evidence that recombinant murine PrP fragment 90-231 (mPrP90-231) contains a biotin-mimicking sequence motif that causes
Alexander Kuzmin et al.
Bioconjugate chemistry, 21(11), 2076-2085 (2010-10-23)
The utility of catalyst-free azide-alkyne [3 + 2] cycloaddition for the immobilization of a variety of molecules onto a solid surface and microbeads was demonstrated. In this process, the surfaces are derivatized with aza-dibenzocyclooctyne (ADIBO) for the immobilization of azide-tagged

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