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Q0750

Sigma-Aldrich

Quinidine hydrochloride monohydrate

technical grade

Sinônimo(s):

6′-Methoxycinchonan-9-ol hydrochloride monohydrate

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About This Item

Fórmula empírica (Notação de Hill):
C20H24N2O2 · HCl · H2O
Número CAS:
6151-40-2
Peso molecular:
378.89
Número CE:
205-001-1
Número MDL:
MFCD00198101
Código UNSPSC:
12352100
ID de substância PubChem:
57654579
NACRES:
NA.22

grau

technical grade

Impurezas

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

cadeia de caracteres SMILES

O.Cl.[H][C@@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@@H](O)c3ccnc4ccc(OC)cc34

InChI

1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19+,20-;;/m0../s1

chave InChI

SGVZDMWHXVXUBY-KAIFKDDSSA-N

Informações sobre genes

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Categorias relacionadas

Aplicação

Studied for pharmacological activity causing energy shifts from mitochondrial respiration to glycolysis

Ações bioquímicas/fisiológicas

Class IA antiarrhythmic; potassium channel blocker.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302 + H312 + H332

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Keisuke Oda et al.
The Journal of pharmacy and pharmacology, 69(12), 1736-1744 (2017-10-06)
Possible interaction of green tea beverage (GT) containing cyclodextrins and high concentration catechins, a drinking water, with P-glycoprotein (P-gp) substrates was examined in vitro and in vivo. Effects of GT on the uptake of rhodamine 123 by LLC-GA5-COL150 cells and intestinal efflux
Miki Fukao et al.
European journal of drug metabolism and pharmacokinetics, 41(6), 819-824 (2015-12-03)
We have recently found an H We investigated the uptake and efflux of quinidine in MDCK cells. The uptake of 100 µM quinidine into MDCK cells was decreased by acidification of extracellular pH or alkalization of intracellular pH. In addition, the
Faisal E Al Jofi et al.
Cytotherapy, 20(5), 650-659 (2018-03-21)
Compelling evidence indicates that metformin, a low-cost and safe orally administered biguanide prescribed to millions of type 2 diabetics worldwide, induces the osteoblastic differentiation of mesenchymal stromal cells (MSCs) through the 5' adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway. As
Rajesh Chavan et al.
Xenobiotica; the fate of foreign compounds in biological systems, 51(3), 251-261 (2020-10-21)
Nafithromycin is a next generation lactone ketolide antibiotic slated to enter phase III clinical development in India for the treatment of CABP as a shorter 800 mg-OD X3 day therapeutic regimen. Nafithromycin exhibits potent activity against MDR Streptococcus pneumoniae including erythromycin and
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Journal of medical virology, 91(7), 1182-1190 (2019-02-26)
Studies aimed at repurposing existing drugs revealed that some antimalarial compounds possess anti-Zika virus (anti-ZIKV) activity. Here, we further tested 14 additional antimalarial drugs and their metabolites or analogs for anti-ZIKV activity using a phenotypic screening approach. We identified four
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