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Q0875

Sigma-Aldrich

Quinidine sulfate salt dihydrate

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About This Item

Fórmula empírica (Notação de Hill):
C40H48N4O4 · H2O4S · 2H2O
Número CAS:
6591-63-5
Peso molecular:
782.94
Número CE:
200-046-3
Número MDL:
MFCD00149346
Código UNSPSC:
12352200
ID de substância PubChem:
24277870
NACRES:
NA.77

Nível de qualidade

200

Impurezas

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

pf

212-214 °C (dec.) (lit.)

originador

Bayer

cadeia de caracteres SMILES

[H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1

chave InChI

ZHNFLHYOFXQIOW-WFTMRWCJSA-N

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Descrição geral

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

Aplicação

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

Ações bioquímicas/fisiológicas

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.
Class IA antiarrhythmic; potassium channel blocker.

Características e benefícios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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