919454

CCW16-PEG₃-BocNH

≥95%

• Sinônimo(s): tert-Butyl (2-(2-(2-(2-(4-(4-(N-Benzyl-2-chloroacetamido)phenoxy)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate, Crosslinker-E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, RNF4-targeting building block, Template for synthesis of targeted protein degrader
• Fórmula empírica (Notação de Hill): C₃₄H₄₃ClN₂O₈
• Peso molecular: 643.17
• Número MDL: MFCD34166223
• Código UNSPSC: 12352200
• NACRES: NA.22

Propriedades

• ligand: CCW16
• Nível de qualidade: 100
• Ensaio: ≥95%
• Formulário: liquid
• adequação da reação: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• grupo funcional: amine
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCOCCOCCOCCNC(OC(C)(C)C)=O)C=C3
• InChI: 1S/C34H43ClN2O8/c1-34(2,3)45-33(39)36-17-18-40-19-20-41-21-22-42-23-24-43-29-13-15-31(16-14-29)44-30-11-9-28(10-12-30)37(32(38)25-35)26-27-7-5-4-6-8-27/h4-16H,17-26H2,1-3H3,(H,36,39)
• chave InChI: ZBIUJJSRBDSDRU-UHFFFAOYSA-N

Descrição

Aplicação

Protein degrader building block CCW16-PEG₃-BocNH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a RING finger protein 4 (RNF4)-recruiting ligand, a PEGylated crosslinker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Outras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable