915858
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) diacrylate
average Mn ~5,800
Sinônimo(s):
PEG-PPG-PEG, Pluronic P-123 diacrylate, Pluronic diacrylate
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About This Item
Fórmula linear:
C3H3O[C2H4O]x[C3H6O]y[C2H4O]zC3H3O2
Código UNSPSC:
51171641
NACRES:
NA.23
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Formulário
solid
Nível de qualidade
peso molecular
average Mn ~5,800
cor
off-white to yellow
temperatura de armazenamento
−20°C
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Aplicação
Poloxamers are nonionic, triblock copolymers containg a central hydrophobic chain of poly(propylene glycol) (PPG) and two terminal hydrophilic chains of poly(ethylene glycol) (PEG). Due to their amphiphilic structure, poloxamer solutions feature temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature, in a reversible process. This characteristic has allowed for these materials to be used as drug carriers for most routes of administration including oral, topical, intranasal, ocular, and parenteral. Acrylate-modified derivatives are most commonly used as thermosensitive hydrogels for drug delivery and 3D bioprinting applications. After casting or printing, the material can be crosslinked to preserve the hydrogel structure.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Carlos R L, et al.
Macromolecules, 49(14), 5179-5189 (2016)
Photopolymerization of Pluronic F127 diacrylate: a colloid-templated polymerization
Manuela D B, et al.
Soft Materials, 7, 4928-4937 (2011)
J J Escobar-Chávez et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 9(3), 339-358 (2007-01-09)
It is, sometimes, desirable to maintain a constant plasma drug concentration within the therapeutically effective concentration range. The use of high viscosity hydromiscible vehicles such as hydrophilic gels, is one of various approaches for controlled drug delivery, and represents an
Christopher J Hansen et al.
Advanced materials (Deerfield Beach, Fla.), 25(1), 96-102 (2012-10-31)
Microvascular multinozzle arrays are designed and fabricated for high-throughput printing of functional materials. Ink-flow uniformity within these multigeneration, bifurcating microchannel arrays is characterized by computer modeling and microscopic particle image velocimetry (micro-PIV) measurements. Both single and dual multinozzle printheads are
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