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902659

Sigma-Aldrich

Amino-PEG6-t-butyl ester

Sinônimo(s):

tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H2N-PEG6-CH2CH2COOtBu

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About This Item

Fórmula empírica (Notação de Hill):
C19H39NO8
Número CAS:
1286281-32-0
Peso molecular:
409.51
Número MDL:
MFCD13184944
Código UNSPSC:
51171641
NACRES:
NA.22

Formulário

liquid

adequação da reação

reagent type: cross-linking reagent

índice de refração

n/D 1.4562

densidade

1.06581 g/mL

grupo funcional

amine
ester

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

InChI

1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3

chave InChI

QGSFECNPSLZGGT-UHFFFAOYSA-N

Categorias relacionadas

Aplicação

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Lot/Batch Number

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Judit Erchegyi et al.
Journal of medicinal chemistry, 59(3), 854-866 (2016-01-21)
CRF mediates numerous stress-related endocrine, autonomic, metabolic, and behavioral responses. We present the synthesis and chemical and biological properties of astressin B analogues {cyclo(30-33)[D-Phe(12),Nle(21,38),C(α)MeLeu(27,40),Glu(30),Lys(33)]-acetyl-h/r-CRF(9-41)}. Out of 37 novel peptides, 17 (2, 4, 6-8, 10, 11, 16, 17, 27, 29, 30
Minoru Ueda et al.
Chemistry, an Asian journal, 6(12), 3286-3297 (2011-08-05)
Affinity chromatography by using ligand-immobilized bead technology is generally the first choice for target exploration of a bioactive ligand. However, when a ligand has comparatively low affinity against its target, serious difficulties will be raised in affinity-based target detection. We
Minoru Ueda et al.
Bioorganic & medicinal chemistry letters, 21(5), 1359-1362 (2011-02-08)
Affinity purification using immunoprecipitation (IP) is an extremely useful method for target profiling of bioactive natural products. We examined IP purification of CMetE, which is a molecular target for potassium isolespedezate (1), a leaf-opening factor of Cassia plant. We studied
Efficient synthesis of small-sized phosphonated dendrons: potential organic coatings of iron oxide nanoparticles
Garofalo A, et al.
New. J. Chem. (2014)
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Parat A, et al.
Journal of Material Chemistry B: Materials for Biology and Medicine (2015)
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Global Trade Item Number

SKUGTIN
902659-250MG4061838694348
902659-1G4061838694263

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