902314

[CpRu(Fmoc-tyrosin)]CF₃CO₂

• Sinônimo(s): Fmoc-protected ruthenium tyrosine amino acid derivative, Peptide radiolabel precursor, [18F]Fluorophenylalanine peptide residue precursor
• Fórmula empírica (Notação de Hill): C₃₁H₂₆F₃NO₇Ru
• Peso molecular: 682.61
• Código UNSPSC: 12352209
• NACRES: NA.26

Propriedades

• Formulário: powder
• adequação da reação: reaction type: Fmoc solid-phase peptide synthesis
• pf: >300 °C
• aplicação(ões): peptide synthesis
• grupo funcional: Fmoc
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O[C]1[CH][CH][C](CC(NC(OCC2C(C=CC=C3)=C3C4=C2C=CC=C4)=O)C(O)=O)[CH][CH]1.F[C-](F)F.O=C=O.[Ru+].c5cccc5

Descrição

Aplicação

The Ritter lab has developed a new method for direct labeling of polypeptides with the [18F]fluoride radiolabel. This Fmoc-protected ruthenium tyrosine is first incorporated into peptides, which is amenable to standard solid-phase peptide synthesis (SPPS) and is tolerant of all 20 canonical amino acids. Subsequent replacement of a single hydrogen with fluorine-18, with only minimal perturbation of the peptide structure, results in a site-specific, radiolabeled peptide tracer for use with positron emission tomography (PET) imaging in the study of various biological applications.

Atenção

Research quantities limited to 10 g.

Outras notas

Site-SpecificDeoxyfluorination of Small Peptides with [18F]Fluoride

Informações legais

Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable