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757810

Sigma-Aldrich

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid

average Mn 1,000 (n~22), cross-linking reagent amine reactive, cross-linking reagent thiol reactive

Sinônimo(s):

Polyethylene glycol, mercaptoPEG acid, mercaptopoly(ethylene glycol) carboxylic acid, mercaptopolyoxyethylene acetic acid, thio-PEG, thiol-PEG-acid, thiol-PEG-carboxylate

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About This Item

Fórmula linear:
HSC2H4O(C2H4O)nCH2CO2H
Número CAS:
Código UNSPSC:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid, average Mn 1,000

forma

solid

peso molecular

PEG average Mn 1,000 (n~22)
average Mn 1,000

adequação da reação

reagent type: cross-linking reagent
reactivity: amine reactive

reagent type: cross-linking reagent
reactivity: thiol reactive

temperatura de transição

Tm 40-45 °C

Ω-final

thiol

α-final

carboxylic acid

arquitetura do polímero

shape: linear
functionality: heterobifunctional

temperatura de armazenamento

−20°C

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Aplicação

  • bioconjugation
  • drug delivery
  • PEG hydrogel
  • crosslinker
  • surface functionalization
Reported applications include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

>604.4 °F

Ponto de fulgor (°C)

> 318 °C


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S M Barber et al.
The journal of physical chemistry. A, 110(13), 4538-4542 (2006-03-31)
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De Vos, K.; et al.
Biosensors And Bioelectronics, 24, 2525-2533 (2009)
Eunjung Kim et al.
Biomaterials, 31(16), 4592-4599 (2010-03-09)
We investigated the synergism between shRNAs against Bcl-xL and doxorubicin (DOX) using aptamer-conjugated polyplexes (APs) in combination cancer therapy. Synergistic and selective cancer cell death was achieved by AP-mediated co-delivery of very small amounts of DOX and Bcl-xL-specific shRNA, which

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