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Sigma-Aldrich

Poly(ethylene glycol) methyl ether thiol

average MN 6,000, chemical modification reagent thiol reactive, methoxy, thiol

Sinônimo(s):

Polyethylene glycol, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, PEG thiol, mPEG thiol

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About This Item

Fórmula linear:
CH3O(CH2CH2O)nCH2CH2SH
Código UNSPSC:
12162002
NACRES:
NA.23

Nome do produto

Poly(ethylene glycol) methyl ether thiol, average Mn 6,000

Formulário

solid

peso molecular

average Mn 6,000

adequação da reação

reagent type: chemical modification reagent
reactivity: thiol reactive

pf

56-61 °C

Mw/Mn

≤1.2

Ω-final

thiol

α-final

methoxy

arquitetura do polímero

shape: linear
functionality: monofunctional

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

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Descrição geral

Poly(ethylene glycol) methyl ether thiol (mPEGthiol) is a thiol-terminated biocompatible polymer widely used in the surfacefunctionalization of gold nanoparticles. Thiol moieties bind with high affinityto gold surfaces by forming a self-assembled monolayer (SAM) through thecovalent thiolate–metal bond. mPEG thiol-coated Au nanoparticles findapplication in the fields of biosensors and drug delivery systems.

Aplicação

Poly(ethylene glycol) methyl ether thiol-coated Au nanoparticles can be used for the determination of melamine T. by an optical method. It can also be used to fabricate switchable super-wetting membranes foroil/water separation.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCL4582
MKCH0719
MKCF5112
MKBW7623V
MKBS3186V

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Amina Ghorbel et al.
Bioelectrochemistry (Amsterdam, Netherlands), 137, 107642-107642 (2020-09-28)
The use of conductive nanoparticles (NPs) was previously proposed as a way to locally amplify the electric field (EF) intensity at the cell membrane to enhance cell electroporation. To achieve this, a close distance between the NPs and the cell
Jairo Pinto Oliveira et al.
Scientific reports, 9(1), 13859-13859 (2019-09-27)
Antibody-coated nanoparticles have recently attracted considerable attention, with the focus falling on diagnostics. Nevertheless, controlled antibody bioconjugation remains a challenge. Here, we present two strategies of bioconjugation with the aim of evaluating the best approach for the coupling of antibodies

Artigos

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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