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729108

Sigma-Aldrich

Poly(ethylene glycol) methyl ether thiol

average MN 800, chemical modification reagent thiol reactive, methoxy, thiol

Sinônimo(s):

Polyethylene glycol, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, PEG thiol, mPEG thiol

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About This Item

Fórmula linear:
CH3O(CH2CH2O)nCH2CH2SH
Código UNSPSC:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) methyl ether thiol, average Mn 800

forma

solid

peso molecular

average Mn 800

adequação da reação

reagent type: chemical modification reagent
reactivity: thiol reactive

Impurezas

≤10% disulfide

temperatura de transição

Tm 32-37 °C

Mw/Mn

≤1.1

Ω-final

thiol

α-final

methoxy

arquitetura do polímero

shape: linear
functionality: monofunctional

temperatura de armazenamento

2-8°C

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Aplicação

Poly(ethylene glycol) methyl ether thiol can be used to functionalize Fe3O4@Au core-shell nanoparticles. The thiolated PEG increases the water solubility and significantly lowers the nanotoxicity.

It can be used as a precursor to synthesize PEG conjugated poly(β-amino ester) polyplexes for gene therapy.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Certificados de análise (COA)

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Visite a Biblioteca de Documentos

Cristina Gentilini, Mariangela Boccalon, and Lucia Pasquato
The Journal of Organic Chemistry, 3308-3308 (2008)
Nisha C. Kalarickal, Stephen Rimmer, Prodip Sarker, and Jean-Christophe Leroux
Macromolecules, 40, 1874-1874 (2007)

Artigos

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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