437336
4-Amino-2-chlorophenol
98%
Sinônimo(s):
3-Chloro-4-hydroxyaniline
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About This Item
Fórmula linear:
H2NC6H3(Cl)OH
Número CAS:
Peso molecular:
143.57
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22
Produtos recomendados
Nível de qualidade
Ensaio
98%
pf
150-153 °C (lit.)
grupo funcional
chloro
cadeia de caracteres SMILES
Nc1ccc(O)c(Cl)c1
InChI
1S/C6H6ClNO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H,8H2
chave InChI
ZYZQSCWSPFLAFM-UHFFFAOYSA-N
Descrição geral
4-Amino-2-chlorophenol (4A2CP) is a chlorinated aniline. Nephrotoxic potential of 4-amino-2-chlorophenol and its comparison with 4-aminophenol, 4-amino-2-chlorophenol, 4-amino-3-chlorophenol and 4-amino-2,6-dichlorophenol using isolated renal cortical cells from male Fischer 344 rats has been investigated.
Aplicação
4-Amino-2-chlorophenol may be used in the synthesis of the following compounds:
- N-(3-chloro-4-hydroxyphenyl)-N′,N′-dimethylurea
- 1,4-diketo-3-((4-[N-(3-chloro-4-hydroxyphenyl)amino]sulfonyl)phenyl)-6-phenylpyrrolo[3,4-c]pyrrole, a novel fluorescent pH-indicator
- 4-(4-aminophenoxy)-N-(4-(4-aminophenoxy) benzylidene)-3-chloroaniline
- 4-(4-amino-3-methylphenoxy)-N-(4-(4-amino-3-methylphenoxy)benzylidene)-3-chloroaniline
- 4-(4-amino-2-methylphenoxy)-N-(4-(4-amino-2-methylphenoxy)benzylidene)-3-chloroaniline
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órgãos-alvo
Respiratory system
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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Synthesis and Characterization of Novel Processable and Flexible Polyimides Containing 3, 6-Di(4-carboxyphenyl) pyromellitic Dianhydride.
Khosa MK, et al.
Advances in Chemistry, 2014 (2014)
Gary O Rankin et al.
Chemico-biological interactions, 222, 126-132 (2014-12-03)
Chlorinated anilines are nephrotoxicants both in vivo and in vitro. The mechanism of chloroaniline nephrotoxicity may occur via more than one mechanism, but aminochlorophenol metabolites appear to contribute to the adverse in vivo effects. The purpose of this study was
Fluorescent materials for pH sensing and imaging based on novel 1,4-diketopyrrolo-[3,4-c] pyrrole dyes.
Aigner D, et al.
Journal of Material Chemistry C, 1(36), 5685-5693 (2013)
C Tixier et al.
Environmental toxicology and chemistry, 20(7), 1381-1389 (2001-07-04)
The degradation products of diuron (photoproducts and metabolites), already described in the literature, were synthesized in order to carry out further investigations. Their ecotoxicity was determined using the standardized Microtox test, and most of the derivatives presented a nontarget toxicity
S K Hong et al.
Toxicology, 110(1-3), 47-58 (1996-06-17)
Aminophenols and halogenated anilines induce nephrotoxicity and mild hepatotoxicity in rats. In this study, the in vivo and in vitro nephrotoxic potential of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol, monochlorinated aminophenols and potential metabolites of 3-chloroaniline, was evaluated. Hepatotoxicity of both compounds was
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