386529

Clorotrimetilsilano

purified by redistillation, ≥99%

• Sinônimo(s): Cloreto de trimetilsilil, TMCS, Trimetilclorosilano
• Fórmula linear: (CH₃)₃SiCl
• Número CAS: 75-77-4
• Peso molecular: 108.64
• Beilstein: 1209232
• Número CE: 200-900-5
• Número MDL: MFCD00000502
• Código UNSPSC: 12352302
• ID de substância PubChem: 24864097
• NACRES: NA.22

Propriedades

• densidade de vapor: 3.7 (vs air)
• Nível de qualidade: 200
• pressão de vapor: 100 mmHg ( 25 °C)
• Ensaio: ≥99%
• Formulário: liquid
• temperatura de autoignição: 752 °F
• purificado por: glass distillation; redistillation
• Lim. expl.: 6.4 %
• Impurezas: <0.1% dichlorodimethylsilane
• índice de refração: n20/D 1.387 (lit.)
• p.e.: 57 °C (lit.)
• pf: −40 °C (lit.)
• densidade: 0.856 g/mL at 25 °C (lit.)
• cadeia de caracteres SMILES: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• chave InChI: IJOOHPMOJXWVHK-UHFFFAOYSA-N

Descrição

Descrição geral

Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions.

Aplicação

Chlorotrimethylsilane (TMSCl) can be used as:       

• A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines.      
• A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents.        
• A trapping agent for the anions generated during acyloin condensation reaction.       
• A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols.
•  A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters.        
• A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides.       
• A reagent in Fischer glycosidation.       
• A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et₃SiH.
• A reagent to synthesize sodium trimethylsilanethiolate (Me₃SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me₃SiSNa from foul-smelling bis(trimethylsilyl)sulfide and sodium methoxide.

Informações de segurança

• Pictogramas: GHS02,GHS06,GHS05
• Palavra indicadora: Danger
• Frases de perigo: H225,H301 + H331,H312,H314
• Declarações de precaução: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Perigos de suplementos: EUH014
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): -18.4 °F - closed cup
• Ponto de fulgor (°C): -28 °C - closed cup
• Equipamento de proteção individual: Faceshields, Gloves, Goggles