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Merck

ESR2

estrogen receptor 2 (ER beta)

Sinônimos:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Espécies:
Human ESR2 (2100), Mouse Esr2 (13983), Rat Esr2 (25149), chicken ESR2 (395575), dog ESR2 (403639), Horse ESR2 (100033964), cow ESR2 (281146), domestic cat ESR2 (101086317), domestic guinea pig Esr2 (100731304), Goat ESR2 (100860823) ...Mais
ID UniProtKB:
Q92731, A8K8K5, O60608, O60685, O60702, O60703, O75583, O75584
ID do gene:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

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Small Molecule - Activator

Número do produto
Descrição
Espécies
N0632
ββ-Dinucleotídeo de nicotinamida adenina, ,
Espécies
human
43410
β-Dinucleotídeo de nicotinamida adenina, ≥95% (HPLC),
Espécies
human
N8285
β-Nicotinamide adenine dinucleotide, pkg of 10 mg (per vial),
Espécies
human
N3014
β-Dinucleotídeo de nicotinamida adenina, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Espécies
human
N8535
β-Nicotinamide adenine dinucleotide, pkg of 50 mg (per vial),
Espécies
human

Small Molecule - Agonist

Número do produto
Descrição
Espécies
PZ0183
ERB-041, ≥98% (HPLC),
Espécies
human
E7887
17α-Ethynylestradiol 3-cyclopentyl ether, ,
Espécies
human
E9750
Estrone, ≥99%,
Espécies
human, mouse, rat

Small Molecule - Allosteric Modulator

Número do produto
Descrição
Espécies
R1402
Raloxifene hydrochloride, solid,
Espécies
human
E0407
Estramustine sodium phosphate, ,
Espécies
human
PHR1852
Raloxifene Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Espécies
human
Y0001134
Raloxifene hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
Y0001135
Raloxifene hydrochloride for peak identification, European Pharmacopoeia (EP) Reference Standard,
Espécies
human

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
I4409
Fulvestrant, >98% (HPLC),
Espécies
human
M6383
2-Methoxyestradiol, powder,
Espécies
human
Y0001399
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
Y0001413
Fulvestrant for system suitability, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
E8750
α-Estradiol, powder, ≥98% (TLC),
Espécies
human, rat

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
SAB4500814
Anti-Estrogen Receptor-β antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunofluorescence
western blot
05-824
Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal, clone 68-4, Upstate®, from rabbit,
Reatividade de espécies
human
Aplicação
immunoprecipitation (IP)
western blot
SAB2702145
Monoclonal Anti-ESR2 antibody produced in mouse, ,
Reatividade de espécies
human, monkey, mouse
Aplicação
ChIP
dot blot
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
MABE290
Anti-Estrogen Receptor β Antibody, clone 9.88, clone 9.88, from mouse,
Reatividade de espécies
human, mouse, rat
Aplicação
immunoprecipitation (IP)
western blot
SAB2100713
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
western blot

Cell Lines

Número do produto
Descrição
Espécies
CLLS1075
MCF10A CELLS ESR2 (-/-), ,
Espécies
human

Small Molecule - Mixed Agonist/Antagonist

Número do produto
Descrição
Espécies
E8750
α-Estradiol, powder, ≥98% (TLC),
Espécies
human, rat
E1024
Estradiol, meets USP testing specifications,
Espécies
human, mouse, rat
E2758
β-Estradiol, BioReagent, powder, suitable for cell culture,
Espécies
human, mouse, rat
E8875
β-Estradiol, ≥98%,
Espécies
human, mouse, rat
E2257
β-Estradiol, powder, γ-irradiated, suitable for cell culture,
Espécies
human, mouse, rat

esiRNA

Número do produto
Descrição
Espécies
EHU900081
MISSION® esiRNA, targeting human ESR2,
Espécies
human