902578

Hydroxy-PEG6-t-butyl ester

≥95%

• Synonym(e): tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate, HO-PEG6-CO-OtBu
• Empirische Formel (Hill-System): C₁₉H₃₈O₉
• CAS-Nummer: 361189-64-2
• Molekulargewicht: 410.50
• UNSPSC-Code: 51171641
• NACRES: NA.22

Eigenschaften

• Assay: ≥95%
• Form: liquid
• Eignung der Reaktion: reagent type: cross-linking reagent
• Brechungsindex: n/D 1.454
• Dichte: 1.068
• Funktionelle Gruppe: ester; hydroxyl
• Lagertemp.: −20°C
• SMILES String: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
• InChI: 1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3
• InChIKey: VGGDPFAYSOSIOK-UHFFFAOYSA-N

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Sonstige Hinweise

Synthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR

Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs: Synthesis and Antitumor Efficacy

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable