902586

Hydroxy-PEG4-t-butyl ester

• Synonym(e): tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate, HO-PEG4-CO-OtBu
• Empirische Formel (Hill-System): C₁₅H₃₀O₇
• CAS-Nummer: 518044-32-1
• Molekulargewicht: 322.39
• MDL-Nummer: MFCD11041117
• UNSPSC-Code: 51171641
• NACRES: NA.22

Eigenschaften

• Assay: ≥95%
• Form: liquid
• Eignung der Reaktion: reagent type: cross-linking reagent
• Brechungsindex: n/D 1.4492
• Dichte: 1.04746 g/mL
• Funktionelle Gruppe: ester; hydroxyl
• Lagertemp.: 2-8°C
• SMILES String: O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
• InChI: 1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
• InChIKey: FJRDXEGYAVAMLB-UHFFFAOYSA-N

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Sonstige Hinweise

Recruiting cytotoxic T cells to folate-receptor-positive cancer cells

Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology

High density orthogonal surface immobilization via photoactivated copper-free click chemistry

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable