902691

Hydroxy-PEG5-t-butyl ester

• Synonym(e): tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• Empirische Formel (Hill-System): C₁₇H₃₄O₈
• CAS-Nummer: 850090-09-4
• Molekulargewicht: 366.45
• MDL-Nummer: MFCD20926402
• UNSPSC-Code: 51171641

Eigenschaften

• Assay: ≥95%
• Form: liquid
• Eignung der Reaktion: reagent type: cross-linking reagent
• Brechungsindex: n/D 1.448
• Dichte: 1.071
• Funktionelle Gruppe: ester; hydroxyl
• Lagertemp.: −20°C
• SMILES String: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Sonstige Hinweise

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable