WISP2
WNT1 inducible signaling pathway protein 2
Synonyms:
CCN5, CT58, CTGF-L
Species:
Human WISP2 (8839), Mouse Wisp2 (22403), Rat Wisp2 (29576), Zebrafish wisp2 (100007759), chicken WISP2 (419192), dog WISP2 (610928), domestic cat WISP2 (101091930), cow WISP2 (534658), sheep WISP2 (101106613), naked mole-rat Wisp2 (101706687)
UniProtKB ID:
Gene ID:
- Human(8839) Summary: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
- Mouse(22403) WNT1 inducible signaling pathway protein 2
- Rat(29576) WNT1 inducible signaling pathway protein 2
- Zebrafish(100007759) WNT1 inducible signaling pathway protein 2
- chicken(419192) WNT1 inducible signaling pathway protein 2
- dog(610928) WNT1 inducible signaling pathway protein 2
- domestic cat(101091930) WNT1 inducible signaling pathway protein 2
- cow(534658) WNT1 inducible signaling pathway protein 2
- sheep(101106613) WNT1 inducible signaling pathway protein 2
- naked mole-rat(101706687) WNT1 inducible signaling pathway protein 2
- domestic guinea pig(100721143) WNT1 inducible signaling pathway protein 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-WISP2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-WISP2, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-WISP2 antibody produced in mouse, clone 1E11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Proteins
Product Number
Description
Species
CTGFL-WISP-2 human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
human