RAD17
RAD17 homolog (S. pombe)
Synonyms:
CCYC, HRAD17, R24L, RAD17SP, RAD24
Species:
Human RAD17 (5884), Mouse Rad17 (19356), Rat Rad17 (310034), cow RAD17 (513600), sheep RAD17 (101118988), domestic guinea pig Rad17 (100726505), naked mole-rat Rad17 (101720200), Domestic Rabbit RAD17 (100339735), fruit fly Rad17 (41779), Horse RAD17 (100065769) ...More
UniProtKB ID:
Gene ID:
- Human(5884) Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
- Mouse(19356) RAD17 homolog (S. pombe)
- Rat(310034) RAD17 homolog (S. pombe)
- cow(513600) RAD17 homolog (S. pombe)
- sheep(101118988) RAD17 homolog (S. pombe)
- domestic guinea pig(100726505) RAD17 homolog (S. pombe)
- naked mole-rat(101720200) RAD17 homolog (S. pombe)
- Domestic Rabbit(100339735) RAD17 homolog (S. pombe)
- fruit fly(41779) CG7825 gene product from transcript CG7825-RA
- Horse(100065769) RAD17 homolog (S. pombe)
- domestic cat(101087298) RAD17 homolog (S. pombe)
- dog(478088) RAD17 homolog (S. pombe)
- Zebrafish(436934) RAD17 homolog (S. pombe)
- chicken(404778) RAD17 homolog (S. pombe)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RAD17 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-RAD17 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-RAD17 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-RAD17 antibody produced in mouse, clone 2G12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-RAD17 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot