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Merck

NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Synonymes:
NF-ATC, NFAT2, NFATc
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(4772) Summary: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
  • Mouse(18018) nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
  • Rat(100361818) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • Domestic Rabbit(100352378) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • naked mole-rat(101697946) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • domestic guinea pig(100730044) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • sheep(101108097) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • Zebrafish(568315) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • cow(511224) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • Horse(100065378) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • domestic cat(101101259) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • dog(483925) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • chicken(420815) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

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Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Espèce(s)
human, rat, mouse

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-NFATC1 (ab1) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry
western blot
Anti-NFATC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-NFATc1 Antibody, clone 1O16 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human
Application
ELISA
affinity binding assay

immunocytochemistry

immunohistochemistry

western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
NFAT Inhibitor, >96% (HPLC), solid,
Espèce(s)
mouse, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Espèce(s)
human, rat, mouse

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human NFATC1,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Nfatc1,
Espèce(s)
mouse