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Merck

LCK

lymphocyte-specific protein tyrosine kinase

Synonyms:
LSK, YT16, p56lck, pp58lck
Species:
UniProtKB ID:
Gene ID:
  • Human(3932) Summary: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
  • Mouse(16818) lymphocyte protein tyrosine kinase
  • Rat(313050) lymphocyte-specific protein tyrosine kinase
  • sheep(100216439) lymphocyte-specific protein tyrosine kinase
  • Domestic Rabbit(100349102) lymphocyte-specific protein tyrosine kinase
  • domestic guinea pig(100728811) lymphocyte-specific protein tyrosine kinase
  • naked mole-rat(101714396) lymphocyte-specific protein tyrosine kinase
  • Zebrafish(414333) lymphocyte-specific protein tyrosine kinase
  • cow(508890) lymphocyte-specific protein tyrosine kinase
  • Horse(100146139) lymphocyte-specific protein tyrosine kinase
  • domestic cat(101098805) lymphocyte-specific protein tyrosine kinase
  • dog(478151) lymphocyte-specific protein tyrosine kinase
  • chicken(396460) lymphocyte-specific protein tyrosine kinase

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Small Molecule - Antagonist

Product Number
Description
Species
Rosmarinic acid, 96%,
Species
human
α-Sexithiophene, ,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Lck Antibody, clone 3A5, clone 3A5, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
Anti-Lck Antibody, clone 2B20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
flow cytometry

immunocytochemistry

immunohistochemistry

western blot
Anti-Phospho-Lck-Y505 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Lck Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
Anti-Phospho-LCK-Y394 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
1-Naphthyl phosphate, 99%,
Species
human
1-Naphthalenesulfonic acid, >50%,
Species
human
2-Naphthalenesulfonic acid, technical grade, 70%,
Species
human
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Species
human
Pazopanib, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Lck,
Species
mouse
MISSION® esiRNA, targeting human LCK,
Species
human