INSIG1
insulin induced gene 1
Synonyms:
CL-6, CL6
Species:
Human INSIG1 (3638), Mouse Insig1 (231070), Rat Insig1 (64194), domestic guinea pig Insig1 (100718114), naked mole-rat Insig1 (101722021), sheep INSIG1 (101106422), Zebrafish insig1 (334189), cow INSIG1 (511899), dog INSIG1 (475554), domestic cat INSIG1 (101087651)
UniProtKB ID:
Gene ID:
- Human(3638) Summary: Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]
- Mouse(231070) insulin induced gene 1
- Rat(64194) insulin induced gene 1
- domestic guinea pig(100718114) insulin induced gene 1
- naked mole-rat(101722021) insulin induced gene 1
- sheep(101106422) insulin induced gene 1
- Zebrafish(334189) insulin induced gene 1
- cow(511899) insulin induced gene 1
- dog(475554) insulin induced gene 1
- domestic cat(101087651) insulin induced gene 1
- chicken(420442) insulin induced gene 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-INSIG1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat, sheep
Application
immunohistochemistry
western blot
western blot