V1255
D-Valine
BioReagent, suitable for cell culture
Synonym(s):
(R)-α-Aminoisovaleric acid, D-2-Amino-3-methylbutanoic acid
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All Photos(4)
About This Item
Linear Formula:
(CH3)2CHCH(NH2)CO2H
CAS Number:
Molecular Weight:
117.15
Beilstein/REAXYS Number:
1721135
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.75
Recommended Products
biological source
synthetic (organic)
Quality Level
product line
BioReagent
form
powder
technique(s)
cell culture | mammalian: suitable
mp
>295 °C (subl.) (lit.)
shipped in
ambient
storage temp.
room temp
SMILES string
CC(C)[C@@H](N)C(O)=O
InChI
1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
InChI key
KZSNJWFQEVHDMF-SCSAIBSYSA-N
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General description
L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.
Application
D-Valine has been used as a supplement in:
- Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture
- endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture
- DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture
Biochem/physiol Actions
D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.
D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
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