SRP8052

CD279 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• Synonym(s): Hepatitis A virus cellular receptor 2, PD-1, Programmed cell death protein 1
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in CHO cells
• assay: ≥98% (SDS-PAGE)
• form: lyophilized
• mol wt: monomer 46 kDa by calculation
• packaging: pkg of 100 μg
• impurities: <0.06 EU/μg endotoxin, tested
• UniProt accession no.: Q15116
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... PDCD1(5133)

Description

General description

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.

Other Notes

The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable