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Key Documents

SRP6561

Sigma-Aldrich

Cathepsin K Active human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

CTSK, CTSO, CTSO3

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

liquid

mol wt

23.5 kDa (115-329 aa)

packaging

pkg of 5 μg
pkg of 50 μg

concentration

0.5 mg/mL

technique(s)

activity assay: suitable

suitability

suitable for molecular biology

UniProt accession no.

P43235

application(s)

life science and biopharma

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CTSK(1513)

General description

Cathepsin K is expressed as procathepsin K, which is the inactive proenzyme of cathepsin K. Cathepsin K is a lysosomal cysteine protease and part of the papain cysteine protease family. It is expressed in osteoclasts. The gene encoding this protein is localized on human chromosome 1q21.

Biochem/physiol Actions

Cathepsin K has a role in bone resorption and remodeling. It has a triple helical collagen hydrolase activity. Mutations in the gene encoding this protein have been linked to pycnodysostosis.

Physical form

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Diana J Leeming et al.
BMC cancer, 8, 180-180 (2008-07-01)
Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of the present study was to determine whether
Familial pycnodysostosis: identification of a novel mutation in the CTSK gene (cathepsin K).
Toral-Lopez J, et al.
Journal of Investigative Medicine, 59(2), 277-280 (2011)
Autocatalytic activation of human cathepsin K.
McQueney M S, et al.
The Journal of Biological Chemistry, 272(21), 13955-13960 (1997)
A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin.
Huang X, et al.
Calcified Tissue International, 96(5), 373-378 (2015)
Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease.
Bobillo L J, et al.
Medicina clinica, 145(7), 281-287 (2015)
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